长链非编码RNA与动物的基因表达调控

doi:10.11843/j.issn.0366-6964.2015.04.001

摘要/Abstract

摘要：

长链非编码RNA（Long noncoding RNA，lncRNA）是一类长度超过200 nt的非编码RNA，没有完整的开放阅读框，不具备编码蛋白质的能力。但是最近的研究表明，lncRNA参与机体内许多重要的生理过程，如基因印记、X染色体失活等。其调节作用主要是通过DNA甲基化、组蛋白修饰、染色质重塑等方式影响基因的表达。同时lncRNA在疾病的发生与发展过程中影响重大，对疾病的诊断与治疗有重要的意义。因此，本文从lncRNA的生物学特性、lncRNA在表观遗传学、转录后水平、转录水平、在干细胞中的作用以及在疾病上的研究内容进行总结分析，阐述lncRNA的研究进展，为进一步研究lncRNA参与调控机体内生理过程的作用机制提供参考。

Abstract:

Long noncoding RNA are a group of endogenous RNA molecules which exceed 200 nt in length，lack complete specific open reading frame，they don’t have the ability to encode proteins.But recent studies have shown that lncRNA participates in many important physiological processes，such as gene imprinting，X chromosome inactivation，and so on.They regulate gene expression mainly through the DNA methylation，Histone modification，chromatin remodeling.At the same time，lncRNA have important effect on the occurrence and development process of disease，and have very important significance to the diagnosis and treatment of disease.Therefore，this article analyzed the biological characteristics of lncRNA，lncRNA in epigenetic，transcriptional level post-transcriptional level，the role in stem cell and the research of the disease，elaborated the research progress of the current lncRNA，provided a reference for further study on the mechanism of lncRNA involved in the regulation of physiological processes.

中图分类号:

S852.2

王康岩，凌英会，章孝荣. 长链非编码RNA与动物的基因表达调控[J]. 畜牧兽医学报, 2015, 46(4): 509-517.

WANG Kang-yan，LING Ying-hui，ZHANG Xiao-rong. Research Progress in Regulation of Gene Expression of Long Noncoding RNA[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2015, 46(4): 509-517.

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